Use of 1-anilino-8-napthalenesulphonate as an ion probe for the potentiometric study of the binding of sulphonamides to bovine serum albumin and plasma.

@article{Angelakou1993UseO1,
  title={Use of 1-anilino-8-napthalenesulphonate as an ion probe for the potentiometric study of the binding of sulphonamides to bovine serum albumin and plasma.},
  author={A T Angelakou and Georgia N. Valsami and Michael Alpha Koupparis and Panayotis E. Macheras},
  journal={The Journal of pharmacy and pharmacology},
  year={1993},
  volume={45 5},
  pages={434-8}
}
The binding of sulphafurazole, sulphamethizole and sulphamethoxazole to bovine serum albumin (BSA) and human plasma has been studied in-vitro by potentiometry using an electrode selective for the ion probe 1-anilino-8-napthalenesulphonate (ANS). The method requires two separate potentiometric titrations of the binder solution with ANS in the absence and in… CONTINUE READING