Use-dependent prolongation of ventricular tachycardia cycle length by type I antiarrhythmic drugs in humans.

@article{Kidwell1993UsedependentPO,
  title={Use-dependent prolongation of ventricular tachycardia cycle length by type I antiarrhythmic drugs in humans.},
  author={Gregory Kidwell and Arnold J. Greenspon and Richard Joseph Greenberg and Kent J Volosin},
  journal={Circulation},
  year={1993},
  volume={87 1},
  pages={118-25}
}
BACKGROUND Type I antiarrhythmic drugs block the cardiac sodium channel in a use-dependent fashion. This use-dependent behavior causes increased drug binding and consequently increased sodium channel blockade at faster stimulation rates. Importantly, the kinetics of drug association and dissociation from the sodium channel differ for each type I antiarrhythmic drug. METHODS AND RESULTS Thirty-five patients receiving type I antiarrhythmic drugs for the treatment of sustained monomorphic… CONTINUE READING

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