Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period

@article{Humm1998UsedependentEO,
  title={Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period},
  author={J. Humm and D. Kozlowski and D. James and J. Gotts and T. Schallert},
  journal={Brain Research},
  year={1998},
  volume={783},
  pages={286-292}
}
For a period of time after unilateral brain injury, surviving neural tissue surrounding the lesion may be vulnerable to extremely high behavioral demand. Previously, we found that lesions of the forelimb representation area of the sensorimotor cortex (FL-SMC) in rats increase in size substantially when the intact forelimb is immobilized with a plaster of paris cast during the first 15 days after surgery, which forces overuse of the impaired forelimb. The present study was designed to determine… Expand
Consequences of forced disuse of the impaired forelimb after unilateral cortical injury
TLDR
It is shown that complete disuse of the impaired forelimb during the first post-operative week renders surviving tissue vulnerable to later over use of the same limb, in effect extending the window of vulnerability in which use-dependent exaggeration of brain injury can occur. Expand
Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?
TLDR
Administration of MK-801 during the casting period spared neural tissue surrounding the lesion and enhanced functional recovery of the impaired forelimb, suggesting a role for NMDA receptor-mediated processes in use-dependent exaggeration of injury. Expand
Attempt-dependent decrease in skilled reaching characterizes the acute postsurgical period following a forelimb motor cortex lesion: An experimental demonstration of learned nonuse in the rat
The notion that shock or diaschisis is a distinctive stage in the recovery process following brain damage has played a formative role in the characterization of brain injury. For example, damage toExpand
Early Training May Exacerbate Brain Damage after Focal Brain Ischemia in the Rat
  • A. Risedal, RJinsheng Zeng, B. Johansson
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1999
TLDR
The middle cerebral artery was ligated distal to the striatal branches in 25 male spontaneously hypertensive rats to investigate if early training without immobilization of the intact forelimb could increase tissue loss and reduce recovery. Expand
Sensorimotor Experience Influences Recovery of Forelimb Abilities but Not Tissue Loss after Focal Cortical Compression in Adult Rats
TLDR
Accumulating evidence is provided that early sensory experience has a beneficial influence on the onset and time course of functional recovery after focal brain injury and increased sensorimotor activity initiated early in an enriched environment induced a rapid and more complete behavioral recovery compared with standard housing. Expand
Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane.
TLDR
Investigating whether intracisternal infusion of basic fibroblast growth factor (bFGF or FGF-2), a potent neurotrophic factor that has been shown to have neuroprotective and plasticity promoting properties in focal stroke and other injury models, could prevent use-dependent exaggeration of injury found it to prevent expansion of the lesion size. Expand
Early exclusive use of the affected forelimb after moderate transient focal ischemia in rats : functional and anatomic outcome.
TLDR
The exclusive use of the affected forelimb immediately after focal ischemia has detrimental effects on sensorimotor function that cannot be attributed to hyperthermia or stress. Expand
Early onset of forced impaired forelimb use causes recovery of forelimb skilled motor function but no effect on gross sensory-motor function after capsular hemorrhage in rats
TLDR
The efficacy of early focused use of an impaired limb after internal capsule hemorrhage is demonstrated and improvements in skilled reaching and coordinated stepping function are found in the FLU-treated group in comparison with the untreated group after ICH. Expand
Experience-dependent neural plasticity in the adult damaged brain.
TLDR
This review summarizes recent findings on the role of experience in reorganizing the adult damaged brain, with a focus on findings from rodent stroke models of chronic upper extremity (hand and arm) impairments. Expand
Training the "less-affected" forelimb after unilateral cortical infarcts interferes with functional recovery of the impaired forelimb in rats.
TLDR
Behavioral experience with the less-affected Forelimb early after unilateral SMC lesions has the potential to increase disuse and dysfunction of the impaired forelimb, consistent with a training-induced exacerbation of learned non-use. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Use-Dependent Exaggeration of Neuronal Injury after Unilateral Sensorimotor Cortex Lesions
TLDR
The results suggest that although behavioral experience can enhance neural growth after brain injury, the region surrounding the injury may be vulnerable to behavioral pressure during the early postlesion period. Expand
Use-dependent structural events in recovery of function.
TLDR
It is hypothesized that behaviorally driven neurotransmitter release relating to forced use of the forelimb may be toxic to surviving tissue that has been partially traumatized by the lesion. Expand
Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rat: physiological, histological and behavioral correlates
TLDR
The entire sensorimotor control system of the anesthetized rat appeared to have been affected by a cortical injury, and axonal degeneration was present in the areas adjacent to the ipsilateral cortical injury site. Expand
Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor.
TLDR
To determine whether a related mechanism might be operating in adult animals recovering from brain damage, MK-801, a non-competitive NMDA receptor antagonist, was administered during the pruning phase in adult rats that had sustained FL-SMC lesions, consistent with the possibility that there may be a functionally important pruning mechanism with a glutamatergic component in adults with FL- SMC lesions. Expand
Recovery of function after brain damage: A theory of the behavioral deficit
The present discussion assumes that recovery of function is not an event but rather a process. When it occurs, this process bridges the gap between the occurrence of the brain injury and theExpand
Subcortical deterioration after cortical damage: effects of diazepam and relation to recovery of function
TLDR
The findings suggest that the long-term disruptive effects of diazepam on recovery of function after AMC lesions may be related to an augmentation of lesion-induced degeneration. Expand
Use-dependent growth of pyramidal neurons after neocortical damage
  • T. Jones, T. Schallert
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
Neither a lesion nor asymmetrical limb use alone could account for the dendritic overgrowth--it depended on aLesion-behavior interaction, and greater sensorimotor impairments were found when thedendritic growth was blocked, suggesting that the neural growth and/or associated limb-use behavior were related to functional recovery from the cortical damage. Expand
"Exuberant" Neuronal Growth After Brain Damage in Adult Rats: The Essential Role of Behavioral Experience
TLDR
It is hypothesized that brain damage can sensitize, or prepare, remaining neural tissue through growth promoting and pruning-like mechanisms so that in the presence of appropriate behavioral pressure, the tissue can be drastically altered to compensate for lost function. Expand
Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct
TLDR
The results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery. Expand
Disruption and recovery of locomotor and manipulatory behavior following cortical lesions in rats.
TLDR
It is demonstrated that removals of frontal cortex disrupted manipulation but not locomotion; damage of medial parietal cortex (sensorimotor cortex) produced the reverse effects; and serial lesions of medialParietal cortex resulted in more rapid recovery of locomotion than damage imposed in a single operation. Expand
...
1
2
3
4
...