Use and validation of HT/HC assays to support 21st century toxicity evaluations.

@article{Patlewicz2013UseAV,
  title={Use and validation of HT/HC assays to support 21st century toxicity evaluations.},
  author={Grace Patlewicz and Ted W. Simon and Katy Olsavsky Goyak and Richard Phillips and Justin Craig Rowlands and Shawn D Seidel and Richard A. Becker},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2013},
  volume={65 2},
  pages={259-68}
}
Advances in high throughput and high content (HT/HC) methods such as those used in the fields of toxicogenomics, bioinformatics, and computational toxicology have the potential to improve both the efficiency and effectiveness of toxicity evaluations and risk assessments. However, prior to use, scientific confidence in these methods should be formally established. Traditional validation approaches that define relevance, reliability, sensitivity and specificity may not be readily applicable. HT… CONTINUE READING