Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors

@article{Douin2004UseAC,
  title={Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors},
  author={Victorine Douin and St{\'e}phanie Bornes and Laurent Cr{\'e}ancier and Philippe Rochaix and Gilles Favre and A. C. Prats and B. Tourret Couderc},
  journal={BMC Biotechnology},
  year={2004},
  volume={4},
  pages={16 - 16}
}
BACKGROUND Polycistronic retroviral vectors that contain several therapeutic genes linked via internal ribosome entry sites (IRES), provide new and effective tools for the co-expression of exogenous cDNAs in clinical gene therapy protocols. For example, tricistronic retroviral vectors could be used to genetically modify antigen presenting cells, enabling them to express different co-stimulatory molecules known to enhance tumor cell immunogenicity. RESULTS We have constructed and compared… CONTINUE READING
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