Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2.

@article{Sol1997UsageOT,
  title={Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2.},
  author={Neil Sol and Françoise Ferchal and Jonathon Braun and Olivier Pleskoff and Carole Tr{\'e}boute and I Ansart and M. A. Alizon},
  journal={Journal of virology},
  year={1997},
  volume={71 11},
  pages={
          8237-44
        }
}
The chemokine receptors CCR-5 and CXCR-4, and possibly CCR-3, are the principal human immunodeficiency virus type 1 (HIV-1) coreceptors, apparently interacting with HIV-1 envelope, in association with CD4. Cell lines coexpressing CD4 and these chemokine receptors were infected with a panel of seven primary HIV-2 isolates passaged in peripheral blood mononuclear cells (PBMC) and three laboratory HIV-2 strains passaged in T-cell lines. The CCR-5, CCR-3, and CXCR-4 coreceptors could all be used by… CONTINUE READING

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