Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment

  title={Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment},
  author={Adelina Jim{\'e}nez-Arellanes and Julieta Luna-Herrera and Jorge Cornejo-Garrido and Sonia L{\'o}pez-Garc{\'i}a and Mar{\'i}a Eugenia Castro-Mussot and Mariana Meckes-Fischer and Dulce Adriana Mata-Espinosa and Brenda Marquina and Javier Torres and Rogelio Hern{\'a}ndez-Pando},
  journal={BMC Complementary and Alternative Medicine},
  pages={258 - 258}
BackgroundNew alternatives for the treatment of Tuberculosis (TB) are urgently needed and medicinal plants represent a potential option. Chamaedora tepejilote and Lantana hispida are medicinal plants from Mexico and their hexanic extracts have shown antimycobacterial activity. Bioguided investigation of these extracts showed that the active compounds were ursolic acid (UA) and oleanolic acid (OA).MethodsThe activity of UA and OA against Mycobacterium tuberculosis H37Rv, four monoresistant… 

Antimycobacterial activity of methanolic plant extract of Artemisia capillaris containing ursolic acid and hydroquinone against Mycobacterium tuberculosis.

Anti-mycobacterial and anti-inflammatory activity of restinga plants: a dual approach in searching for new drugs to treat severe tuberculosis

Evaluating the anti-mycobacterial activity of extracts and fractions in vitro from plant species collected in the Restinga of Jurubatiba enabled identifying Kielmeyera membranacea and Eremanthus crotonoides as the most promising studied species in searching for new anti-TB compounds with dual activity.

Medicinal Plants, an Important Reserve of Antimycobacterial and Antitubercular Drugs: An Update

Since (-)-licarin A, ursolic acid and oleanolic acid have been evaluated as antitubercular compounds, these metabolites are candidates proposed feasible to be proposed for development of antituberculosis drugs.

Evaluation of the antimicrobial activity of Cinnamomum zeylanicum essential oil and trans-Cinnamaldehyde against resistant Mycobacterium tuberculosis

Results indicate that CzeyEO and TCin are potential candidates for the treatment of drug-resistant tuberculosis in combination therapy with INH and RIF.

Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves

Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. saligna and their ability to inhibit the growth of M. tuberculosis was predicted and was confirmed to possess significant antimycobacterial activity.



Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.

Sesquiterpene lactones, costunolide and dehydrocostuslactone, were the compounds responsible for the antimycobacterial activity against Mycobacterium tuberculosis H37Rv with MICs of 6.25 and 12.5 mg/L, respectively.

Antimycobacterial triterpenoids from Lantana hispida (Verbenaceae).

In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus.

The results suggest that TGF-beta1 antagonistic activity is responsible, at least in part, for the therapeutic efficacy of this plant to treat humans with renal disease.

Antibacterial and antiparasitic activity of oleanolic acid and its glycosides isolated from marigold (Calendula officinalis).

Oleanolic acid and its glycosides can be considered as potential therapeutic agents for bacterial growth and survival, influenced cell morphology and enhanced the autolysis of Gram-positive bacteria suggesting that bacterial envelopes are the target of its activity.

Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.

Oleanolic acid was identified as an anti-HIV principle from several plants, including Rosa woodsii, Prosopis glandulosa, Phoradendron juniperinum, Syzygium claviflorum, and Hyptis capitata, and Ternstromia gymnanthera.

Pentacyclic triterpenoic acids: new chemoprotective compounds. Minireview.

Both Ursolic acid and oleanolic acid are relatively non-toxic and could be use as chemopreventive/chemoprotective agents in clinical praxis and the mechanisms by which they act are poorly understood.

Secondary Metabolites from Chamaedora tepejilote (Palmae) are Active against Mycobacterium tuberculosis

The bioactivity‐guided fractionation of Chamaedora tepejilote hexane extract led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, β‐sitosterol and ursolic acid, which showed activity against Mycobacterium tuberculosis H37Rv.

Ursolic acid: an anti- and pro-inflammatory triterpenoid.

Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.