Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment

@article{JimnezArellanes2013UrsolicAO,
  title={Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment},
  author={Adelina Jim{\'e}nez-Arellanes and Julieta Luna-Herrera and Jorge Cornejo-Garrido and Sonia L{\'o}pez-Garc{\'i}a and Mar{\'i}a Eugenia Castro-Mussot and Mariana Meckes-Fischer and Dulce Adriana Mata-Espinosa and Brenda Marquina and Javier Torres and Rogelio Hern{\'a}ndez-Pando},
  journal={BMC Complementary and Alternative Medicine},
  year={2013},
  volume={13},
  pages={258 - 258}
}
BackgroundNew alternatives for the treatment of Tuberculosis (TB) are urgently needed and medicinal plants represent a potential option. Chamaedora tepejilote and Lantana hispida are medicinal plants from Mexico and their hexanic extracts have shown antimycobacterial activity. Bioguided investigation of these extracts showed that the active compounds were ursolic acid (UA) and oleanolic acid (OA).MethodsThe activity of UA and OA against Mycobacterium tuberculosis H37Rv, four monoresistant… 

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Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves

TLDR
Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. saligna and their ability to inhibit the growth of M. tuberculosis was predicted and was confirmed to possess significant antimycobacterial activity.
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