Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis.

@article{Ullevig2011UrsolicAP,
  title={Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis.},
  author={Sarah L. Ullevig and Qingwei Zhao and Debora A. Zamora and Reto H Asmis},
  journal={Atherosclerosis},
  year={2011},
  volume={219 2},
  pages={409-16}
}
AIMS Accelerated atherosclerosis is a major diabetic complication initiated by the enhanced recruitment of monocytes into the vasculature. In this study, we examined the therapeutic potential of the phytonutrients ursolic acid (UA) and resveratrol (RES) in preventing monocyte recruitment and accelerated atherosclerosis. METHODS AND RESULTS Dietary supplementation with either RES or UA (0.2%) protected against accelerated atherosclerosis induced by streptozotocin in high-fat diet-fed LDL… CONTINUE READING
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