Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.

@article{Zhai2018UrsolicAP,
  title={Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.},
  author={Maocai Zhai and Junyi Guo and Haiyan Ma and Wei Shi and David Jou and Dan Gui Yan and Tianshu Liu and Jingwen Tao and Jialin Duan and Yina Wang and Sheng Li and Jiagao Lv and Chenglong Li and Jiayuh Lin and Cuntai Zhang and Li Lin},
  journal={Atherosclerosis},
  year={2018},
  volume={271},
  pages={
          128-135
        }
}
BACKGROUND AND AIMS Abdominal aortic aneurysms (AAA) is a chronic inflammatory disease in which signal transducer and activator of transcription 3 (STAT3), and disintegrin and metalloproteinase 17 (ADAM17) play important roles. However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA. The objective of this study was to characterize the potential effect of UA on the… CONTINUE READING
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