Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.

@article{Zhang2010UrsolicAO,
  title={Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.},
  author={Yu-xi Zhang and Chui-ze Kong and Lin-hui Wang and Jin-yi Li and Xian-kui Liu and Bin Xu and Chuanliang Xu and Yinghao Sun},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={109 4},
  pages={764-73}
}
Androgen-independent prostate cancers express high levels of Bcl-2, and this over-expression of Bcl-2 protects prostate cancer cells from undergoing apoptosis. Ursolic acid (UA) has demonstrated an anti-proliferative effect in various tumor types. The aim of this study is to evaluate the difference between UA-induced apoptosis in androgen-dependent prostate cancer cell line LNCaP cells and androgen-independent prostate cancer cell line LNCaP-AI cells and to reveal the molecular mechanisms… CONTINUE READING

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