Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.

@article{Lin2013UrsolicAI,
  title={Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.},
  author={Jiumao Lin and Youqin Chen and Lihui Wei and Zhenfeng Hong and Thomas Joseph Sferra and Jun Peng},
  journal={International journal of oncology},
  year={2013},
  volume={43 5},
  pages={1666-74}
}
Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, STAT3, Akt and p70S6K pathways that are known to malfunction in many types of cancer including colorectal cancer (CRC). Therefore, suppression of tumor angiogenesis through targeting… CONTINUE READING

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