Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells.

@article{Zheng2012UrsolicAA,
  title={Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells.},
  author={Qing-you Zheng and Feng-suo Jin and Chen Yao and Tong Zhang and Guo-hui Zhang and Xing Ai},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={419 4},
  pages={741-7}
}
Ursolic acid (UA) has shown the anti-tumor properties against a number of human cancers both in vivo and in vitro, however, its effect in bladder cancer and the corresponding mechanisms of action remain largely unknown. Here we found that UA dose-dependently induced growth inhibition and apoptosis in human bladder cancer T24 cells, and activation of AMP-activated protein kinase (AMPK) may contribute to the process. Our Western-blot results demonstrated a significant AMPK activation after UA… CONTINUE READING
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