Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

@article{Lu2011UrsolicAI,
  title={Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and I$\kappa$B kinase $\beta$/nuclear factor-$\kappa$B-mediated inflammatory pathways in mice},
  author={Jun Lu and Dong-Mei Wu and Yuanlin Zheng and Bin Hu and Wei Cheng and Zi‐feng Zhang and Qun Shan},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={1658-1667}
}
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113 Citations
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Ursolic acid administration significantly improved behavioral performance of D-gal-treated mice in step-through test and Morris water maze task and significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-κB p65 nuclear translocation in the prefrontal cortex of D -gal- treated mice.
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