Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

@article{Lu2011UrsolicAI,
  title={Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and I$\kappa$B kinase $\beta$/nuclear factor-$\kappa$B-mediated inflammatory pathways in mice},
  author={Jun Lu and Dong-Mei Wu and Yuanlin Zheng and Bin Hu and Wei Cheng and Zi‐feng Zhang and Qun Shan},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={1658-1667}
}
Evidence suggests that obesity-induced cognitive impairments are driven by in brain inflammatory responses and inflammation-mediated brain insulin resistance. Ursolic acid (UA), a triterpenoid compound, has many important biological functions, including antioxidant and anti-inflammatory activities. Here, we evaluated the effect of UA on cognitive impairment induced by a high-fat diet (HFD), and we explored the potential mechanisms mediating this effect. Results showed that UA administration… 
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