Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

@article{Lu2011UrsolicAI,
  title={Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and I$\kappa$B kinase $\beta$/nuclear factor-$\kappa$B-mediated inflammatory pathways in mice},
  author={Jun Lu and Dong-Mei Wu and Yuanlin Zheng and Bin Hu and Wei Cheng and Zi‐feng Zhang and Qun Shan},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={1658-1667}
}

Figures from this paper

Troxerutin Counteracts Domoic Acid–Induced Memory Deficits in Mice by Inhibiting CCAAT/Enhancer Binding Protein β–Mediated Inflammatory Response and Oxidative Stress
TLDR
It is shown that troxerutin inhibits cyclin-dependent kinase 1 expression, enhances type 1 protein phosphatase α dephosphorylation, and abolished MEK/ERK1/2/C/EBP β activation, which subsequently reverses the memory impairment observed in the DA-treated mice.
Ursolic acid improves domoic acid-induced cognitive deficits in mice.
α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet.
TLDR
It is demonstrated that α-LA significantly increases the expression of BDNF in the hippocampus of obese ovariectomized rats fed HFD, possibly by improving lipid metabolism, enhancing insulin sensitivity and reversing central inflammation.
Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice.
  • Qun Shan, Yuanlin Zheng, F. Liu
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014
High-salt- and cholesterol diet-associated cognitive impairment attenuated by tannins-enriched fraction of Emblica officinalis via inhibiting NF-kB pathway
TLDR
This study confirms that EOT may be a promising therapy in ameliorating the neurotoxicity of HSCD; however further studies are warranted to elucidate the exact mechanism of action of EOT.
Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities.
TLDR
Results indicated that ursolic acid may be a potential drug for reducing I/R‑IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF‑κB activities.
Rosuvastatin Attenuates High-Salt and Cholesterol Diet Induced Neuroinflammation and Cognitive Impairment via Preventing Nuclear Factor KappaB Pathway
TLDR
The results suggest that HSCD-triggered inflammatory response and cognitive impairment may be associated with NF-κB signaling pathway and treatment with rosuvastatin could be a potential new therapeutic strategy for sporadic dementia of AD.
Tetrahydropalmatine Alleviates Hyperlipidemia by Regulating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation by Inhibiting the TLR4-NF-κB Pathway
TLDR
Data indicate that THP attenuates HLP through a variety of effects, including antioxidative stress, anti-ER stress, and anti-inflammatory effects.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.
TLDR
Ursolic acid administration significantly improved behavioral performance of D-gal-treated mice in step-through test and Morris water maze task and significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-κB p65 nuclear translocation in the prefrontal cortex of D -gal- treated mice.
Troxerutin protects against high cholesterol-induced cognitive deficits in mice.
TLDR
The results suggest that troxerutin could be recommended as a possible candidate for the prevention and therapy of cognitive deficits in type 2 diabetes mellitus and Alzheimer's disease.
Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity
TLDR
Oral administration of quercetin significantly improved the behavioural performance of high‐cholesterol‐fed old mice in both a step‐through test and the Morris water maze task, and suggest that AMPK activated by quercETin may be a potential target to enhance the resistance of neurons to age‐related diseases.
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
TLDR
It is shown that obesity causes endoplasmic reticulum (ER) stress, which leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptors substrate–1 (IRS-1).
Pomegranate Flower Extract Diminishes Cardiac Fibrosis in Zucker Diabetic Fatty Rats: Modulation of Cardiac Endothelin-1 and Nuclear Factor-kappaB Pathways
TLDR
It is demonstrated that six-week treatment with PGF extract in Zucker diabetic fatty rats reduced the ratios of van Gieson-stained interstitial collagen deposit area to total left ventricular area and perivascular collagen deposit areas to coronary artery media area in the heart.
NGF‐Dependent Activation of TrkA Pathway: A Mechanism for the Neuroprotective Effect of Troxerutin in D‐Galactose‐Treated Mice
TLDR
Administration of troxerutin to D‐gal‐injected mice attenuated cognitive impairment and brain oxidative stress through the activation of NGF/TrkA signaling pathway.
NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system
TLDR
A large body of research has been documented to support the concept that IKKβ/NF-κB represents a general cause of various metabolic dysfunctions under overnutrition.
...
1
2
3
4
5
...