Ursolic acid enhances mouse liver regeneration after partial hepatectomy

@article{Jin2012UrsolicAE,
  title={Ursolic acid enhances mouse liver regeneration after partial hepatectomy},
  author={Yong-ri Jin and Jing-Ling Jin and Cheng-hao Li and Xi-Xu Piao and N G Jin},
  journal={Pharmaceutical Biology},
  year={2012},
  volume={50},
  pages={523 - 528}
}
Context: Ursolic acid is a pentacyclic triterpenoid which has hepatoprotective and antihepatotoxic activities. Objective: This study investigated whether ursolic acid is able to stimulate liver regeneration in partially hepatectomized mice. Materials and methods: Ursolic acid or the vehicle solution was orally administered to the experimental, sham-operated and vehicle-treated group mice for 7 days, positive control animal (mice) was treated with recombinant human hepatocyte growth factor… 
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Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells
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Results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-κB/CREB2, and cytochrome c/caspase pathways.
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It is concluded that the new synthetic ursolic acid derivative IUA induces proliferation inhibition and apoptosis of osteosarcoma cells in vitro and in vivo via the down-regulation of the JNK signaling pathway, making it a promising agent for the prevention and treatment of human osteosARcoma.
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