Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).


Tryptophan hydroxylase 1 (Tph-1) initiates the biosynthesis of peripheral serotonin. As peripheral serotonin suppresses bone formation, inhibitor of Tph-1 provides a useful tool to discover anabolic agents for osteoporosis. In the present study, series of ursolic acid (UA) derivatives were synthesized, and their inhibitory activity on serotonin biosynthesis… (More)
DOI: 10.1016/j.ejps.2015.04.021