Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways
@article{Wang2011UrsolicAA, title={Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-$\kappa$B mediated inflammatory pathways}, author={Yong-Jian Wang and Jun Lu and Dong-Mei Wu and Zi-hui Zheng and Yuanlin Zheng and Xiao-hui Wang and Jie Ruan and Xiao Sun and Qun Shan and Zi‐feng Zhang}, journal={Neurobiology of Learning and Memory}, year={2011}, volume={96}, pages={156-165} }
54 Citations
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It is shown that troxerutin inhibits cyclin-dependent kinase 1 expression, enhances type 1 protein phosphatase α dephosphorylation, and abolished MEK/ERK1/2/C/EBP β activation, which subsequently reverses the memory impairment observed in the DA-treated mice.
Ursolic acid improves domoic acid-induced cognitive deficits in mice.
- Biology, ChemistryToxicology and applied pharmacology
- 2013
Low molecular weight heparin prevents lipopolysaccharide induced-hippocampus-dependent cognitive impairments in mice.
- BiologyInternational journal of clinical and experimental pathology
- 2015
Low-molecular-weight heparin (LMWH) treatment protects against sepsis-induced cognitive impairments by attenuating hippocampal microglial activation, cytokine and oxidative stress production, disruption of blood-brain barrier, and the loss of synaptic plasticity related proteins.
Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway
- BiologyFront. Neurol.
- 2018
Novel evidence is provided that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NFκB signaling pathway.
Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages.
- Biology, ChemistryJournal of agricultural and food chemistry
- 2014
Findings suggest that ursolic acid may ameliorate colitis by regulating NF-κB and MAPK signaling pathways via the inhibition of LPS binding to TLR4 on immune cells.
Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model
- Biology, ChemistryJournal of Chemical Neuroanatomy
- 2016
Neuroprotection of Rotenone induced Parkinsonism by Ursolic acid in PD mouse model.
- BiologyCNS & neurological disorders drug targets
- 2020
The results obtained have suggested that UA significantly reduced the overexpression of α-Synuclein and regulated the phosphorylation of survival-related kinases (Akt and ERK) apart from alleviating the behavioral abnormalities and protecting the dopaminergic neurons from oxidative stress and neuroinflammation.
Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury
- Biology, MedicineDrug design, development and therapy
- 2016
Ursolic acid can act as a PPARγ agonist to improve the metalloprotease/anti-metalloproteinase balance, possibly by inhibiting the activation of the MAPK signaling pathway, thereby attenuating cerebral ischemia and reperfusion injury.
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways.
- Biology, ChemistryInternational immunopharmacology
- 2016
Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation
- Biology, MedicineActa Pharmacologica Sinica
- 2014
Ursolic acid treatment significantly ameliorates CIA in mice via suppression of Th17 and differentiation, and may be useful for the treatment of autoimmune arthritis and other Th17-related diseases.
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