Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.

@article{Zhang2006UrsolicAA,
  title={Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.},
  author={Wei Zhang and Di Hong and Yueyang Zhou and Yinan Zhang and Qiang Shen and Jing-Ya Li and Li-hong Hu and Jia Li},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1760 10},
  pages={
          1505-12
        }
}
Protein tyrosine phosphatase 1B (PTP1B) is a key element in the negative regulation of the insulin signaling pathway and may play an important role in diabetes and obesity. We identified ursolic acid, a natural pentacyclic triterpenoid that occurs widely in traditional Chinese medicinal herbs, as an inhibitor of PTP1B by screening an extract library of the traditional Chinese medicinal herbs used a diabetes clinic. By modifying urosolic acid, we designed and synthesized a derivative with a K(i… CONTINUE READING

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