Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

@article{Okada2008UrsodeoxycholicAS,
  title={Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.},
  author={Kosuke Okada and Junichi Shoda and Keiko Taguchi and Jonathan M. Maher and Kaoru Ishizaki and Yoshimi Inoue and Makio Ohtsuki and Nobuharu Goto and Koichi Takeda and Hirotoshi Utsunomiya and Koji Oda and Eiji Warabi and Tetsuro Ishii and Keiko Osaka and Ichinosuke Hyodo and Masayuki Yamamoto},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 4},
  pages={G735-47}
}
The protective action of ursodeoxycholic acid (UDCA) in cholestatic liver diseases may be mediated by choleresis, detoxification, and cytoprotection against oxidative stress. Nrf2, one transcription factor, serves as a cellular stress sensor and is a key regulator for hepatic induction of detoxifying enzymes, antioxidative stress genes, and numerous Mrp family members. We aimed to investigate whether UDCA induces hepatic Mrp expression along with that of detoxifying enzymes and antioxidative… CONTINUE READING
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