Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence

@article{Akare2006UrsodeoxycholicAM,
  title={Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence},
  author={Sandeep Akare and Samira Jean-Louis and Wemin Chen and D. J. Wood and A. Powell and Jesse D. Martinez},
  journal={International Journal of Cancer},
  year={2006},
  volume={119}
}
Agents that can modulate colonic environment and control dysregulated signaling are being evaluated for their chemopreventive potential in colon cancer. Ursodeoxycholate (UDCA) has shown chemopreventive potential in preclinical and animal models of colon cancer, but the mechanism behind it remains unknown. Here biological effects of UDCA were examined to understand mechanism behind its chemoprevention in colon cancer. Our data suggests that UDCA can suppress growth in a wide variety of cancer… Expand
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