Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.

@article{Rodrigues1998UrsodeoxycholicAM,
  title={Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.},
  author={Cec{\'i}lia M. P. Rodrigues and Guangsheng Fan and Patrick Y.D. Wong and Betsy T. Kren and Clifford J. Steer},
  journal={Molecular medicine},
  year={1998},
  volume={4 3},
  pages={
          165-78
        }
}
BACKGROUND The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly, hepatocyte cell death from bile acid-induced toxicity occurs more frequently from apoptosis than from necrosis. However, both processes appear to involve the mitochondrial membrane permeability transition (MPT). In this study, we determined the inhibitory effect of UDCA on deoxycholic acid (DCA)-induced MPT in isolated… CONTINUE READING
Highly Cited
This paper has 140 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 110 citations

140 Citations

0510'99'03'08'13'18
Citations per Year
Semantic Scholar estimates that this publication has 140 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 48 references

A novel role for ursodeoxycholic acid in modulating apoptosis in rat liver , isolated rat hepatocytes and human hepatoma cells

  • Rodrigues CMP, G Fan, X Ma, D Brites, BT Kren, CJ Steer
  • 1997

Glycoursodeoxycholic acid ( GUDC ) inhibits cholangiocyte apoptosis : A mechanism of GUDC cytoprotection

  • FG Que, VA Phan, VH Phan, NF LaRusso, GJ Gores
  • Hepatology
  • 1997