Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells.

@article{Dubreuil2013UrsodeoxycholicAI,
  title={Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells.},
  author={Marta Dubreuil and S{\'i}lvia Ruiz-Gasp{\`a} and N{\'u}ria Gua{\~n}abens and Pilar Peris and L San Emeterio Alvarez and Ana Monegal and Andr{\'e}s Combal{\'i}a and Albert Pares},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2013},
  volume={33 7},
  pages={1029-38}
}
BACKGROUND Osteoporosis resulting from decreased bone formation is a common complication in patients with chronic cholestasis. Lithocholic acid (LCA) and bilirubin may play a role in osteoporosis given that both substances have detrimental effects on survival of human osteoblasts, the cells involved in bone formation. AIMS As ursodeoxycholic acid (UDCA) improves cholestasis, we have assessed if this bile acid may neutralize the harmful effects of LCA, bilirubin and sera from jaundiced… CONTINUE READING