Ursodeoxycholic acid in the treatment of liver diseases.

  title={Ursodeoxycholic acid in the treatment of liver diseases.},
  author={S Saksena and Rakesh Tandon},
  journal={Postgraduate medical journal},
  volume={73 856},
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholeresis. Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established. Newer indications include its use in the… CONTINUE READING


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