Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

@inproceedings{Mueller2015UrsodeoxycholicAE,
  title={Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity},
  author={Michaela Mueller and Anders Thorell and Thierry Claudel and Pooja Jha and Harald C. K{\"o}feler and Carolin Lackner and B Hoesel and Guenter Fauler and Tatjana Stojakovi{\'c} and Curt Einarsson and Hanns-Ulrich Marschall and Michael H Trauner},
  booktitle={Journal of hepatology},
  year={2015}
}
BACKGROUND & AIMS Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD) are still poorly understood. Here we aimed to explore the molecular and biochemical mechanisms of ursodeoxycholic acid (UDCA) in modulating the cross-talk between liver and visceral white adipose tissue (vWAT) regarding BA and cholesterol metabolism and fatty acid/lipid partitioning in morbidly obese NAFLD patients. METHODS In… CONTINUE READING
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