Ursodeoxycholic acid attenuates colonic epithelial secretory function.

  title={Ursodeoxycholic acid attenuates colonic epithelial secretory function.},
  author={Orlaith B. Kelly and Magdalena S. Mroz and Joseph Ward and Carolina Colliva and Michael Scharl and Roberto Pellicciari and John F. Gilmer and Padraic G Fallon and Alan Frederick Hofmann and Aldo Roda and Frank E. Murray and Stephen J. Keely},
  journal={The Journal of physiology},
  volume={591 9},
Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly metabolised by colonic bacteria to ursodeoxycholic acid (UDCA), the effects of which on epithelial transport are poorly characterised. Here, we investigated the role of UDCA in the regulation of colonic epithelial secretion. Cl(-) secretion was measured across voltage-clamped… CONTINUE READING
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