Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis

@article{Magouliotis2017UrsodeoxycholicAI,
  title={Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis},
  author={Dimitrios E. Magouliotis and Vasiliki S. Tasiopoulou and Alexis A. Svokos and Konstantina Svokos and Christina Chatedaki and Eleni Sioka and Dimitris Zacharoulis},
  journal={Obesity Surgery},
  year={2017},
  volume={27},
  pages={3021-3030}
}
We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis… Expand
The use of Ursolit for gallstone prophylaxis following bariatric surgery: a randomized-controlled trial
TLDR
Administration of UDCA significantly decreased gallstone formation at 6 months at following BS, and a trend towards a reduction in prescribed comorbidity medications was noted within-groups during the follow-up period, as compared to baseline, with no between-group differences. Expand
The Necessity for Routine Administration of Ursodeoxycholic Acid After Bariatric Surgery
TLDR
The authors suggest the implementation of routine postoperative administration of UDCA in clinical practice, especially after RYGB, instead of concomitant prophylactic cholecystectomy, as being a safe preventive option. Expand
Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: statistical analysis plan for a randomised controlled trial (UPGRADE trial)
TLDR
The UPGRADE trial will show if prophylactic use of UDCA reduces the incidence of symptomatic gallstone disease after bariatric surgery as well as the number of cholecystectomies and side effects. Expand
Effectiveness of Ursodeoxycholic Acid in the Prevention of Cholelithiasis After Sleeve Gastrectomy
TLDR
UDCA 500 mg once daily for 6 months postoperatively is effective and well tolerated to prevent CL at midterm after SG and is recommended in all patients after SG with an intact preoperative gallbladder. Expand
Ursodeoxycholic acid for the prevention of gallstone and subsequent cholecystectomy following gastric surgery: A systematic review and meta‐analysis
Patients who undergo gastric surgery are prone to form postsurgical gallstones. Debates still exist about the need for prevention and the selection of preventive methods. No studies had been reportedExpand
Ursodeoxycholic Acid for 6 Months After Bariatric Surgery Is Impacting Gallstone Associated Morbidity in Patients with Preoperative Asymptomatic Gallstones
TLDR
UDCA for 6 months after bariatric surgery seems to reduce the incidence of gallstone-associated morbidity when compared to the current literature, calling the concept of prophylactic concomitant cholecystectomy in patients with asymptomatic gallstones into question while paving the way for a future clinical trial. Expand
The incidence of gall stones after bariatric surgery and its association with weight loss
TLDR
The incidence of Gallstone (GS) formation in patients underwent bariatric surgery and the influence of weight loss on GS formation was high and routine US is recommended every 3, 6, 9 and 12 months during the first year after BS. Expand
Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass: a meta-analysis.
TLDR
Comparing the incidence rates of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass in people with obesity with a meta-analysis of cohort studies found participants receiving SG had a significantly lower incidence than those receiving RYGB. Expand
Increased Incidence of Symptomatic Cholelithiasis After Bariatric Roux-En-Y Gastric Bypass and Previous Bariatric Surgery: a Single Center Experience
TLDR
Patients with previous bariatric surgery or patients planned for RYGB are at high risk to develop postoperative symptomatic gallbladder disease and there was a significant difference between the type of the bariatric procedure and the incidence of symptomatic cholecystectomy after the operation. Expand
Is It Safe to Recommend Cholecystectomy Whenever Gallstones Develop After Bariatric Surgery?
TLDR
Compared with Non-Bar patients, LC in Post- Bar patients showed not only similar morbimortality, readmissions, and conversions but also even a higher same-day discharge rate and a trend to lower operative times. Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Ursodeoxycholic Acid in the Prevention of Gallstone Formation after Bariatric Surgery: A Meta-analysis
TLDR
UDCA can prevent gallstone formation after bariatric surgery and is heterogeneous with I2 of 61.9%, the directions of the effect are all consistently in favor of UDCA. Expand
Randomized, Prospective Comparison of Ursodeoxycholic Acid for the Prevention of Gallstones after Sleeve Gastrectomy
TLDR
The incidence of gallstones is higher than previously estimated in SG patients and UDCA significantly lowers the gallstone formation rate at 6 months postoperatively. Expand
Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy
TLDR
The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity, and preoperative dyslipidemia and rapid loss of excess weight within the first 3 months of LSG were the risk factors that significantly predicted CL postoperatively. Expand
Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid.
TLDR
UDCA 500 mg once daily for 6 months is efficient to prevent CL 1 year after SG, but the twice-daily doses seem to be more effective after RYGB. Expand
The effect of ursodeoxycholic acid therapy on gallstone formation in the morbidly obese during rapid weight loss.
TLDR
Morbid obesity is associated with gallbladder bile supersaturated with cholesterol and can be prevented by ursodeoxycholic acid therapy, and there was no correlation between the risk of developing gallstones and pretreatment bile composition or the degree of weight loss. Expand
Gallstone Formation Prophylaxis After Gastric Restrictive Procedures for Weight Loss: A Randomized Double-Blind Placebo-Controlled Trial
TLDR
A daily dose of 500 mg of ursodeoxycholic acid for 6 months is effective prophylaxis for gallstone formation following gastric restrictive procedures. Expand
Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study.
TLDR
This pilot study confirms the high incidence of gallstone formation (71% of assessed patients) associated with rapid weight loss in patients undergoing gastric bypass and highlights the significant risk of gallstones formation in this patient cohort even when prevention strategies are utilized. Expand
Incidence of symptomatic gallstones after gastric bypass: is prophylactic treatment really necessary?
TLDR
Most newly formed gallstones after gastric bypass are likely asymptomatic, prophylactic cholecystectomy is not indicated, and ursodiol therapy may be better reserved for symptomatic patients who refuse surgery. Expand
A Double-Blind Placebo-controlled Trial of Ursodeoxycholic Acid in the Prevention of Gallstones during Weight Loss after Vertical Banded Gastroplasty
TLDR
UDCA is fully effective in preventing gallstone formation following VBG in patients who follow the prescribed regimen, and this results suggest that UDCA is full effective in Preventing cholelithiasis during the period of weight loss. Expand
Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight.
TLDR
It is concluded that ursodeoxycholic acid prevents lithogenic changes in bile and the formation of gallstones in obese subjects during loss of weight. Expand
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