Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis

@article{Magouliotis2017UrsodeoxycholicAI,
  title={Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis},
  author={Dimitrios E. Magouliotis and Vasiliki S. Tasiopoulou and Alexis A. Svokos and Konstantina A. Svokos and Christina Chatedaki and Eleni Sioka and Dimitris Zacharoulis},
  journal={Obesity Surgery},
  year={2017},
  volume={27},
  pages={3021-3030}
}
We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis… 

The impact of ursodeoxycholic acid on gallstone disease after bariatric surgery: a meta-analysis of randomized control trials.

Ursodeoxycholic acid for the prevention of gallstones and subsequent cholecystectomy after bariatric surgery: a meta-analysis of randomized controlled trials

Prophylactic use of UDCA after bariatric surgery prevents both gallstone formation and symptomatic GD and reduces the need for cholecystectomy.

The use of Ursolit for gallstone prophylaxis following bariatric surgery: a randomized-controlled trial

Administration of UDCA significantly decreased gallstone formation at 6 months at following BS, and a trend towards a reduction in prescribed comorbidity medications was noted within-groups during the follow-up period, as compared to baseline, with no between-group differences.

Ursodeoxycholic acid for the prevention of gall stones after laparoscopic sleeve gastrectomy: a prospective controlled study

Compared to no treatment, UDCA 500 mg once daily for 12 months after LSG is effective in reducing gallstone formation at 1 year and high BMI and dyslipidemia are the independent preoperative factors significantly associated with stone development.

Effect of ursodeoxycholic acid on gallstone formation after bariatric surgery: An updated meta‐analysis

This study aimed to investigate the effect of UDCA on gallstone formation after bariatric surgery in patients without preoperative gallstones.

The Necessity for Routine Administration of Ursodeoxycholic Acid After Bariatric Surgery

The authors suggest the implementation of routine postoperative administration of UDCA in clinical practice, especially after RYGB, instead of concomitant prophylactic cholecystectomy, as being a safe preventive option.

Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: statistical analysis plan for a randomised controlled trial (UPGRADE trial)

The UPGRADE trial will show if prophylactic use of UDCA reduces the incidence of symptomatic gallstone disease after bariatric surgery as well as the number of cholecystectomies and side effects.

Effectiveness of Ursodeoxycholic Acid in the Prevention of Cholelithiasis After Sleeve Gastrectomy

UDCA 500 mg once daily for 6 months postoperatively is effective and well tolerated to prevent CL at midterm after SG and is recommended in all patients after SG with an intact preoperative gallbladder.

Ursodeoxycholic acid for the prevention of gallstone and subsequent cholecystectomy following gastric surgery: A systematic review and meta‐analysis

Patients who undergo gastric surgery are prone to form postsurgical gallstones. Debates still exist about the need for prevention and the selection of preventive methods. No studies had been reported
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