Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.

@article{Weingarden2016UrsodeoxycholicAI,
  title={Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.},
  author={Alexa R. Weingarden and Chi R Chen and Ningning Zhang and Carolyn T Graiziger and Peter I Dosa and Clifford J. Steer and Megan K. Shaughnessy and James R. Johnson and Michael J. Sadowsky and Alexander Khoruts},
  journal={Journal of clinical gastroenterology},
  year={2016},
  volume={50 8},
  pages={624-30}
}
GOALS To test whether ursodeoxycholic acid (UDCA) is inhibitory to Clostridium difficile and can be used in the treatment of C. difficile-associated ileal pouchitis. BACKGROUND The restoration of secondary bile metabolism may be the key mechanism for fecal microbiota transplantation (FMT) in treating recurrent C. difficile infections (RCDI). Therefore, it… CONTINUE READING

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