Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.

@article{Mortiboys2013UrsocholanicAR,
  title={Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.},
  author={Heather Jane Mortiboys and Jan O Aasly and Oliver Bandmann},
  journal={Brain : a journal of neurology},
  year={2013},
  volume={136 Pt 10},
  pages={3038-50}
}
Previous drug screens aiming to identify disease-modifying compounds for Parkinson's disease have typically been based on toxin-induced in vitro and in vivo models of this neurodegenerative condition. All these compounds have failed to have a reliable disease-modifying effect in subsequent clinical trials. We have now established a novel approach, namely to screen an entire compound library directly in patient tissue to identify compounds with a rescue effect on mitochondrial dysfunction as a… CONTINUE READING
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