Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis.

  title={Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis.},
  author={M. C. Chen and Christopher S Mudge and David Jichael Klumpp},
  journal={American journal of physiology. Renal physiology},
  volume={291 4},
Interstitial cystitis (IC) is a chronic bladder inflammatory disease of unknown etiology that shares similarities with Crohn's disease and psoriasis. IC, often regarded as a neurogenic cystitis, is associated with urothelial lesions that likely compromise the bladder permeability barrier and thereby contribute to patient morbidity. Here, we use a murine model of neurogenic cystitis to investigate the mechanism of urothelial lesion formation and find that urothelial apoptosis induces formation… CONTINUE READING
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