• Corpus ID: 33376969

Urothelial dysplasia of the bladder: diagnostic features and clinical significance.

@article{LopezBeltran2013UrothelialDO,
  title={Urothelial dysplasia of the bladder: diagnostic features and clinical significance.},
  author={Antonio Lopez‐Beltran and Rodolfo Montironi and Alfredo Vidal and Marina Scarpelli and Liang Cheng},
  journal={Analytical and quantitative cytopathology and histopathology},
  year={2013},
  volume={35 3},
  pages={
          121-9
        }
}
The 2004 World Health Organization classification system for urothelial neoplasia identifies urothelial dysplasia (low-grade intraurothelial neoplasia) as a premalignant lesion of the urothelium. Although diagnostic criteria of urothelial dysplasia have been improved in recent years, there is a frequent lack of interobserver reproducibility. Follow-up studies suggest that dysplasia is a marker for urothelial instability and disease progression in up to 19% of patients, thus supporting an active… 
Dysplasia and carcinoma in situ of the urinary bladder.
TLDR
The pathologic features and clinical significance of urothelial dysplasia and carcinoma in situ are presented with emphasis on differential diagnosis from common flat lesions with atypia.
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Detailed molecular studies have revealed that urothelial CIS may also be divided into luminal and basal subtypes, but luminal subtype is much more common, and it has been shown that in many cases, luminal type of urothalial CIS might undergo a class switch to basal type during progression to an invasive carcinoma.
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The main purpose of this chapter is to review the previously described cytologic criteria of LGPUC in urinary specimens and to define appropriate circumstances that enable the diagnosis of LGUN.
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TLDR
A novel and “easy to use” algorithm is constructed for a clear, standardized and evidence-based pathological diagnosis of flat non-neoplastic urothelial lesions in order to predict clinical behaviour and allow tailored patient management.
Precursor Lesions of Urologic Malignancies.
TLDR
The clinical importance and histologic criteria are well established for the known precursor lesions of the most common malignancies throughout the genitourinary tract, but further investigation is warranted at the molecular level to better understand the pathogenesis of these lesions.
Best Practices Recommendations in the Application of Immunohistochemistry in the Bladder Lesions: Report From the International Society of Urologic Pathology Consensus Conference
TLDR
The bladder working group of the 2013 ISUP Conference on Best Practices Recommendation in the Application of Immunohistochemistry (IHC) discussed 5 settings in which IHC is commonly used in clinical practice and found that there is no ideal marker or established panel to confirm urothelial differentiation.
Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions.
TLDR
The results showed that studied molecules are not suitable for direct detection of CSC in urothelial carcinoma tissue sections, but an expression of molecules CD24 and CD133 is significantly related to uroclinical carcinoma grade and stage, which are both important prognostic indicators and therefore an expressionof these markers might have a potential prognostic value.
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