Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-κB pathway.

@article{Li2017UrotensinII,
  title={Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-κB pathway.},
  author={Jing Li and P Zhao and Ting Hao and Dan Wang and Yu Wang and Yang-Zi Zhu and Yu-qing Wu and Cheng-hua Zhou},
  journal={The Journal of endocrinology},
  year={2017},
  volume={232 2},
  pages={
          165-174
        }
}
Urotensin II (U-II), a cyclic peptide originally isolated from the caudal neurosecretory system of fishes, can produce proinflammatory effects through its specific G protein-coupled receptor, GPR14. Neuropathic pain, a devastating disease, is related to excessive inflammation in the spinal dorsal horn. However, the relationship between U-II and neuropathic pain has not been reported. This study was designed to investigate the effect of U-II antagonist on neuropathic pain and to understand the… CONTINUE READING
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