Urotensin II induces migration of endothelial progenitor cells via activation of the RhoA/Rho kinase pathway.

@article{Xu2009UrotensinII,
  title={Urotensin II induces migration of endothelial progenitor cells via activation of the RhoA/Rho kinase pathway.},
  author={Shengkai Xu and Hong Jiang and B Wu and Jian Yang and Sisi Chen},
  journal={The Tohoku journal of experimental medicine},
  year={2009},
  volume={219 4},
  pages={283-8}
}
Urotensin II (UII) is a vasoactive peptide with many potent effects in the cardiorenovascular system and may be involved in the pathogenesis of atherosclerosis. Cardiovascular risk factors are often accompanied by reduced numbers of endothelial progenitor cells (EPCs) and their impaired migratory capacity. However, the role of UII in the migration of EPCs has not been reported so far. The aim of this study was to investigate whether UII influences the chemotactic function of bone marrow-derived… CONTINUE READING