Urotensin II in end-stage renal disease: an inverse correlate of sympathetic function and cardiac natriuretic peptides.

@article{Mallamaci2005UrotensinII,
  title={Urotensin II in end-stage renal disease: an inverse correlate of sympathetic function and cardiac natriuretic peptides.},
  author={Francesca Mallamaci and Sebastiano Cutrupi and Patrizia Pizzini and Giovanni Tripepi and Carmine Zoccali},
  journal={Journal of nephrology},
  year={2005},
  volume={18 6},
  pages={727-32}
}
BACKGROUND Urotensin II (UTN) is a peptide highly conserved across species with disparate effects on the vascular system and it is currently unclear whether high plasma UTN levels play a vasculotoxic or a vasculoprotective role. METHODS In this study, we investigated the relationship between plasma UTN and sympathetic activity and cardiac natriuretic hormones in 191 hemodialysis (HD) patients without clinical evidence of heart failure. RESULTS Plasma UTN was significantly higher in patients… CONTINUE READING

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