Urotensin II evokes potent vasoconstriction in humans in vivo.

  title={Urotensin II evokes potent vasoconstriction in humans in vivo.},
  author={Felix B{\"o}hm and John Pernow},
  journal={British journal of pharmacology},
  volume={135 1},
The peptide urotensin II (U II) evokes potent vasoconstriction in non-human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation or no response. It is therefore of importance to determine the vascular effect of U II in humans in vivo. U II (0.1 - 300 pmol min(-1)) was infused into the brachial artery of nine healthy volunteers. Changes in forearm blood flow (FBF) were determined by venous occlusion plethysmography. U II… CONTINUE READING