Urotensin II causes fatal circulatory collapse in anesthesized monkeys in vivo: a "vasoconstrictor" with a unique hemodynamic profile.

  title={Urotensin II causes fatal circulatory collapse in anesthesized monkeys in vivo: a "vasoconstrictor" with a unique hemodynamic profile.},
  author={Y. Zhu and Z. Wang and Y. C. Zhu and L. Zhang and R. Oakley and C. W. Chung and K. Lim and H. Lee and M. L. Ozoux and W. Linz and M. B{\"o}hm and E. Kostenis},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={286 3},
  • Y. Zhu, Z. Wang, +9 authors E. Kostenis
  • Published 2004
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
  • Urotensin II (UII) is a vasoactive peptide that has recently emerged as a likely contributor to cardiovascular physiology and pathology. Acute infusion of UII into nonhuman primates results in circulatory collapse and death; however, the exact cause of death is not well understood. This study was undertaken to elucidate the mechanism underlying the fatal cardiovascular event on UII application in vivo in nonhuman primates. To this end, cynomolgus monkeys (n = 4) were anesthetized and tracheal… CONTINUE READING
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