Urotensin-II-Mediated Reactive Oxygen Species Generation via NADPH Oxidase Pathway Contributes to Hepatic Oval Cell Proliferation

@article{Yu2015UrotensinIIMediatedRO,
  title={Urotensin-II-Mediated Reactive Oxygen Species Generation via NADPH Oxidase Pathway Contributes to Hepatic Oval Cell Proliferation},
  author={Xiaotong Yu and Pengyan Wang and Zheng-ming Shi and Kung Dong and P. Feng and Hongxia Wang and Xuejian Wang},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
Urotensin II (UII), a somatostatin-like cyclic peptide, is involved in tumor progression due to its mitogenic effect. Our previous study demonstrated that UII and its receptor UT were up-regulated in human hepatocellular carcinoma (HCC), and exogenous UII promoted proliferation of human hepatoma cell line BEL-7402. Hepatic progenitor cell (HPCs) are considered to be one of the origins of liver cancer cells, but their relationship with UII remains unclear. In this work, we aimed to investigate… Expand
The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells
TLDR
The data suggested an important effect of UII in hepatocellular carcinoma metastasis, which mainly involved NADPH oxidase‐derived ROS through JNK activation and UT played an additional role in regulating hepatoma cells migration and invasion. Expand
Urotensin II: an inflammatory cytokine.
TLDR
The roles UII plays in inflammatory diseases are reviewed and it is shown that UII is involved in the process of inflammatory injury and plays a key role in the onset and development of inflammatory diseases. Expand
Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients
TLDR
The results indicated that UTR may be regarded as a novel biomarker to predict outcomes following radical liver resection and as a potential therapeutic target to inhibit invasion and metastasis of HCC. Expand
Expression of FOXO6 is Associated With Oxidative Stress Level and Predicts the Prognosis in Hepatocellular Cancer
TLDR
FOXO6 expression can be used as a biomarker for deterioration and prognosis of liver cancer, which may provide a novel treatment target for HCC therapy. Expand
Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells
TLDR
The results indicate that HU strongly inhibited peripheral blood mesenchymal stromal cells (PBMSC) proliferation by cell cycle arrest in S phase, and that, consequently, PBMSC acquire senescence‐related phenotypical changes. Expand
Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF‐&bgr;/ smads pathways in rat heart
TLDR
Results revealed the crosstalk between TGF‐&bgr;1/Smads and Nrf2/ antioxidant response elements (ARE) pathways in myocardial remodeling through the interaction between Smad7 and NRF2. Expand
The Effect of Local Renin Angiotensin System in the Common Types of Cancer
The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locallyExpand
RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen
TLDR
This study revealed some novel genes that participate in the signaling pathways for egg-white synthesis and secretion along with some well-known functional genes that help to understand the mechanisms involved in albumen biosynthesis. Expand
Identification of Potential Biomarkers in Human Prostate Cancer Using Bioinformatics Analysis
Prostate Cancer (PCa) is one of the leading causes of cancer-related deaths among the men around the world. In this study, we aim to identify candidate biomarkers in PCa using bioinformatics analysisExpand

References

SHOWING 1-10 OF 43 REFERENCES
Up-Regulation of Urotensin II and Its Receptor Contributes to Human Hepatocellular Carcinoma Growth via Activation of the PKC, ERK1/2, and p38 MAPK Signaling Pathways
TLDR
Results provide the first evidence that up-regulation of the UII/UT system may enhance proliferation of the human hepatoma cell line at least in part via PKC, ERK1/2, and p38 MAPK signaling pathways, and may provide novel therapeutic targets for inhibiting human hepatocellular carcinoma. Expand
Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells*
TLDR
Novel insight is provided into the molecular circuitry of PEITC-induced cell death involving ROS production due to inhibition of complex III and OXPHOS and the Rho-0 variants of LNCaP and PC-3 cells also resisted PEitC-mediated autophagy. Expand
Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells
TLDR
Findings suggest that hU-II may play a novel role in pulmonary hypertension by promoting remodeling processes via activation of NADPH oxidases and increased proliferation in PASMCs. Expand
Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway
TLDR
Findings suggest that CBG can act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells. Expand
Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver
TLDR
In DEN-induced precancerous liver lesions, the UII/UT system was up-regulated, which may contribute to the pathogenesis of liver cancer through a PKC- or ERK1/2-dependent pro-mitogenic pathway in an autocrine/paracrine manner. Expand
Urotensin II Inhibits Skeletal Muscle Glucose Transport Signaling Pathways via the NADPH Oxidase Pathway
TLDR
UII increased ROS production by NADPH oxidase, leading to the inhibition of signaling pathways involving glucose transport, such as AKT/PKC/ERK, and implies a role for UII at the molecular level in glucose homeostasis, and possibly in skeletal muscle insulin resistance in T2DM. Expand
NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer.
TLDR
Findings reveal a new function of p22(phox) in tumor angiogenesis and tumor growth, and suggest that p 22( phox) is a potential novel target for prostate cancer treatment. Expand
Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor
TLDR
The mitogenic action of UII is focused on and its underlying cellular mechanisms and potential physiological/pathophysiological role in various human diseases are discussed. Expand
Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells
TLDR
It is suggested that PPCSE-induced HO-1 expression is mediated by a PC-PLC/PKCδ/NADPH oxidase-dependent PDGFR/PI3K/Akt pathway in bEnd.3 cells. Expand
ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells
TLDR
Findings herein suggest that Nox5‐derived ROS and subsequent depletion of PKCζ and JNK inactivation play a critical role in modulating intracellular signaling cascades involved in the proliferation and survival of PCa cells. Expand
...
1
2
3
4
5
...