Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice

  title={Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice},
  author={Seçkin Engin and Elif Nur Barut and Burak Barut and M. Kadioglu Duman and Cansu Kaya and Gokcen Kerimoglu and Arzu Ozel},
  journal={Supportive Care in Cancer},
  • Seçkin Engin, Elif Nur Barut, +4 authors Arzu Ozel
  • Published 2019
  • Medicine
  • Supportive Care in Cancer
  • PurposeThe aim of the present study was to evaluate the potential uroprotective effect of pantoprazole (PPZ) in a mouse model of cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) due to its antioxidant and anti-inflammatory properties.MethodsBalb/c mice received a single intraperitoneal (i.p.) injection of CP (300 mg/kg) to induce HC. PPZ (20, 50, and 100 mg/kg/day;i.p.) was administered for 3 consecutive days before the induction of HC. Mesna (30 mg/kg;i.p.) was administered 20 min… CONTINUE READING
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