Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice

  title={Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice},
  author={Seçkin Engin and Elif Nur Barut and Burak Barut and Mine Kadioglu Duman and Cansu Kaya and G{\"o}kçen Keri̇moğlu and Arzu Ozel},
  journal={Supportive Care in Cancer},
PurposeThe aim of the present study was to evaluate the potential uroprotective effect of pantoprazole (PPZ) in a mouse model of cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) due to its antioxidant and anti-inflammatory properties.MethodsBalb/c mice received a single intraperitoneal (i.p.) injection of CP (300 mg/kg) to induce HC. PPZ (20, 50, and 100 mg/kg/day;i.p.) was administered for 3 consecutive days before the induction of HC. Mesna (30 mg/kg;i.p.) was administered 20 min… 

The Uroprotective Efficacy of Total Ginsenosides in Chinese Ginseng on Chemotherapy with Cyclophosphamide

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Double benefit of metformin treatment: improved bladder function in cyclophosphamide-induced cystitis and enhanced cytotoxicity in cancer cells

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Could Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?

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Pantoprazole impairs fracture healing in aged mice

P pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation.

The inhibitory effect of trimetazidine on detrusor contractility - a potential repositioning of trimetazidine for the treatment of overactive bladder.

Preclinical evidence is provided that TMZ would be a potential candidate to treat disorders related to the overactivity of the bladder and caused a concentration-dependent relaxation of the tissue possibly through its actions on Ca2+ transients and K+ channels.

Effect of a Low Dose of Carvedilol on Cyclophosphamide-Induced Urinary Toxicity in Rats—A Comparison with Mesna

In conclusion, carvedilol did not counteract the injury caused in the urinary bladders but restored kidney function, presumably via its antioxidant and anti-inflammatory properties.



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Compared with the classical efficacy of mesna with three different doses of resveratrol on cyclophosphamide-induced HC in rats, marked bladder protection was found in 20 and 40 mg/kg RES applications compared to the control group, but this protection was weaker than with mesna.

Protective effect of S-allylcysteine against cyclophosphamide-induced bladder hemorrhagic cystitis in mice.

Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels.

  • T. HamsaG. Kuttan
  • Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2012

Protective role of Ipomoea obscura (L.) on cyclophosphamide-induced uro- and nephrotoxicities by modulating antioxidant status and pro-inflammatory cytokine levels

I. obscura can ameliorate CP-induced bladder and renal toxicities by modulating antioxidant status and proinflammatory cytokine levels, as evident from the decrease in BUN, serum creatinine levels as well as an increase in body weight.

Protective Effect of Thymoquinone against Cyclophosphamide-Induced Hemorrhagic Cystitis through Inhibiting DNA Damage and Upregulation of Nrf2 Expression

Results confirm that, TQ ameliorates the CYP-induced hemorrhagic cystitis in mice through reduction in the oxidative stress, inhibition of the DNA damage and through increased expression of Nrf2 in the bladder tissues.

Participation of TNF-alpha and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis.

The involvement of cytokines TNF-alpha and IL-1 has been investigated in a mouse model of cyclophosphamide (CYP)-induced hemorrhagic cystitis. Male Swiss mice (25-30 g) received CYP in a single i.p.

Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage

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Effects of pantoprazole on ulcer healing delay associated with NSAID treatment

It is concluded that, along with acid suppression, pantoprazole exerts acid-independent effects on ulcer healing, which can be ascribed to a decrease in tissue oxidation and apoptosis.