Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.

@article{Xu2001UroplakinAA,
  title={Uroplakin as a marker for typing metastatic transitional cell carcinoma on fine-needle aspiration specimens.},
  author={Xiaowei Xu and Tim Thomas Sun and Prabodh K. Gupta and Pingan Zhang and Joseph F Nasuti},
  journal={Cancer},
  year={2001},
  volume={93 3},
  pages={216-21}
}
BACKGROUND Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previous study demonstrated positive staining in 66% of metastatic transitional cell carcinoma (TCC) cases and negative staining in all other tumors (including breast, ovarian, lung… CONTINUE READING

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