Uromodulin-associated kidney disease.

@article{Bleyer2011UromodulinassociatedKD,
  title={Uromodulin-associated kidney disease.},
  author={Anthony J. Bleyer and Martina Živn{\'a} and Stanislav Kmoch},
  journal={Nephron. Clinical practice},
  year={2011},
  volume={118 1},
  pages={
          c31-6
        }
}
Uromodulin (Tamm-Horsfall glycoprotein) is the most common protein excreted in the urine of healthy individuals, yet its function remains unclear. Mutations in the UMOD gene encoding uromodulin result in a marked decrease in the synthesis of uromodulin, as well as the accumulation of abnormal uromodulin in tubular cells, leading to tubular cell death. UMOD gene mutations are responsible for the autosomal dominant inheritance of chronic interstitial disease, leading to the need for renal… CONTINUE READING

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