Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor.

@article{Su1997UromodulinAT,
  title={Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor.},
  author={S. J. Su and Karen L Chang and T M Lin and Yi Hui Huang and Thomas M. Yeh},
  journal={Journal of immunology},
  year={1997},
  volume={158 7},
  pages={3449-56}
}
Effects of uromodulin (URO) and Tamm-Horsfall protein (THP), the most abundant proteins in the urine of pregnant and normal women, respectively, on the induction of TNF-alpha secretion and tissue factor (TF) expression of human monocytes were studied. THP, URO, and its fragments stimulated human mononuclear cells to proliferate and secrete TNF-alpha. The release of URO and THP-induced TNF-alpha in monocytes was dependent upon protein tyrosine kinase activation that results in tyrosine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2016
View 2 Excerpts

Uromodulin in kidney injury: an instigator, bystander, or protector?

American journal of kidney diseases : the official journal of the National Kidney Foundation • 2012

Similar Papers

Loading similar papers…