• Corpus ID: 132290456

Urolithins, pomegranate ellagitannin microbial metabolites, as potential modulators of cell and molecular events associated with colorectal cancer: in vitro vs.: human studies= Potencial de las urolitinas, metabolitos microbianos derivados de los elagitaninos de la granada, como moduladores de proce

@inproceedings{Snchez2016UrolithinsPE,
  title={Urolithins, pomegranate ellagitannin microbial metabolites, as potential modulators of cell and molecular events associated with colorectal cancer: in vitro vs.: human studies= Potencial de las urolitinas, metabolitos microbianos derivados de los elagitaninos de la granada, como moduladores de proce},
  author={N{\'u}{\~n}ez S{\'a}nchez and Mar{\'i}a Angeles},
  year={2016}
}

References

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Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells.

TLDR
ET, EA, UA and UB showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells, suggesting that the BRB seeds could be a potential source of anti- cancer ET.

Time course production of urolithins from ellagic acid by human gut microbiota.

TLDR
Bacteria from C. coccoides group (or genera co-occurring in vivo with this group) seem to be involved in production of different urolithins, and these microorganisms implicated is of high interest.

The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy–6H–dibenzopyran–6– one derivatives by the colonic microflora of healthy humans

TLDR
The potential systemic biological effects of pomegranate juice ingestion should be attributed to the colonic microflora metabolites rather than to the polyphenols present in the juice.

The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).

TLDR
The results suggest that physiologically relevant concentrations of these gut microbiota-derived metabolites could modulate ABCG2/BCRP-mediated transport processes and mechanisms of cancer drug resistance.

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

TLDR
Preliminary evidence is shown of the anti-inflammatory, anticarcinogenic, antiglycative, antioxidant, and antimicrobial effects of urolithins, supporting their potential contribution to the health effects attributed to pomegranate and ellagitannin-rich foods.

The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells.

TLDR
The mechanisms behind the cancer preventive properties of foods rich in flavan-3-ols and caffeoylquinic acids are not associated with metabolic pathways directly linked to the Eph-ephrin system, but the ellagitannin-derived colonic metabolite urolithin D was able to exert remarkable and selective EphA-epHRin-A inhibition, which might impact on prostate cancer prevention.

MicroRNAs associated with initiation and progression of colonic polyp: a feasibility study.

A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis

TLDR
It is found that BRB suppositories seem sufficient for regressing rectal polyps in patients with FAP, and the MBD-seq assay revealed more demethylated transcription start sites (TSS) in BRB-treated adenomas from the responders.

Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans.

TLDR
Results show that processing does not modify the potential health effects of strawberry polyphenols, and the release of ellagic acid from ellagitannins is not a relevant factor affecting the microbial metabolism.
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