Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model.

@article{Guada2017UrolithinAM,
  title={Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model.},
  author={Melissa Guada and Raghu Ganugula and Manicka V. Vadhanam and Majeti N V Ravi Kumar},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2017},
  volume={363 1},
  pages={58-65}
}
Cumulative kidney toxicity associated with cisplatin is severe and there is no clear consensus on the therapeutic management of the same. The pathogenesis involves activation of inflammatory and apoptotic pathways; therefore, regulating these pathways offers protection. Given the anti-inflammatory and antioxidant effects of urolithin A, a gut microbial… CONTINUE READING