Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm.

@article{Deng2003UrokinasetypePA,
  title={Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm.},
  author={Gary Gang Deng and Baby Martin-McNulty and Drew A. Sukovich and Ana Freay and Meredith Halks-Miller and Therese C Thinnes and David J. Loskutoff and Peter Carmeliet and William P. Dole and Yi-xin Wang},
  journal={Circulation research},
  year={2003},
  volume={92 5},
  pages={510-7}
}
We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E-deficient (apoE-/-) mice treated with angiotensin II (Ang II). In the present study, we tested the hypothesis that uPA is essential for AAA formation in this model. An osmotic minipump containing Ang II (1.44 mg/kg per day) was implanted subcutaneously into 7- to 11-month-old male mice for 1 month. Ang II induced AAA in 9… CONTINUE READING