Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells

  title={Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells},
  author={Michael Sean Pepper and Jean Dominique Vassalli and R. Montesano and Lelio Orci},
  journal={The Journal of Cell Biology},
  pages={2535 - 2541}
Cellular migration is an essential component of invasive biological processes, many of which have been correlated with an increase in plasminogen activator production. Endothelial cell migration occurs in vivo during repair of vascular lesions and angiogenesis, and can be induced in vitro by wounding a confluent monolayer of cells. By combining the wounded monolayer model with a substrate overlay technique, we show that cells migrating from the edges of an experimental wound display an increase… CONTINUE READING
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