Urokinase-type plasminogen activator gene regulation by polyomavirus middle-T antigen.

  title={Urokinase-type plasminogen activator gene regulation by polyomavirus middle-T antigen.},
  author={Daniel Besser and Marc Urich and Minori Sakaue and A S Messerschmitt and Kurt Ballmer-Hofer and Yoshikuni Nagamine},
  volume={11 11},
Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regulated by middle-T, the urokinase-type plasminogen activator (uPA) gene seems to be of primary importance for the development of the transformed phenotype. We have found that the uPA… CONTINUE READING

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