Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.

@article{Makarova2011UrokinasetypePA,
  title={Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.},
  author={Anastasia M Makarova and Tatiana V Lebedeva and Taher Nassar and Abd Al-Roof Higazi and Jing Xue and Maria E Carinato and Khalil H Bdeir and Douglas B Cines and Victoria Stepanova},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 26},
  pages={23044-53}
}
Urokinase plasminogen activator (uPA) and PA inhibitor type 1 (PAI-1) are elevated in acute lung injury, which is characterized by a loss of endothelial barrier function and the development of pulmonary edema. Two-chain uPA and uPA-PAI-1 complexes (1-20 nM) increased the permeability of monolayers of human pulmonary microvascular endothelial cells (PMVECs) in vitro and lung permeability in vivo. The effects of uPA-PAI-1 were abrogated by the nitric-oxide synthase (NOS) inhibitor L-NAME (N(D… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-2 of 2 references

uPA Induces Endothelial Permeability via eNOS Activation 23052 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M. Conese, A. Nykjaer, C. M. Petersen, O. Cremona, R. Pardi, Andrea
  • JULY
  • 2011

uPA Induces Endothelial Permeability via eNOS Activation

  • S. R. Thom, V. M. Bhopale, D. J. Mancini, T. N. Milovanova
  • J. Biol. Chem. 283,
  • 2008

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