Urokinase-type and tissue-type plasminogen activators are essential for in vitro invasion of human melanoma cells.

@article{Meissauer1991UrokinasetypeAT,
  title={Urokinase-type and tissue-type plasminogen activators are essential for in vitro invasion of human melanoma cells.},
  author={A. Meissauer and Michael D. Kramer and Michael Hofmann and Lars Johan Erkell and E. Dominic Jacob and Volker Schirrmacher and Georg Brunner},
  journal={Experimental cell research},
  year={1991},
  volume={192 2},
  pages={
          453-9
        }
}
This study evaluates the contribution of two types of plasminogen activators (PAs; tissue-type PA (tPA) versus urokinase-type PA (uPA) toward the invasiveness of human melanoma cells in a novel in vitro assay. We identified two human melanoma cell lines, MelJuso and MeWo, expressing uPA or tPA as shown at mRNA, protein, and enzyme activity level. MelJuso cells produced uPA as well as plasminogen activator inhibitor-1 (PAI-1). The latter was, however, not sufficient to neutralize the cell… CONTINUE READING
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