Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.

Abstract

Up-regulation of urokinase receptors is common during tumor progression and thought to promote invasion and metastasis. Urokinase receptors bind urokinase and a set of beta1 integrins, but it remains unclear to what degree urokinase receptor/integrin binding is important to beta1 integrin signaling. Using site-directed mutagenesis, single amino acid mutants… (More)

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Cite this paper

@article{Wei2007UrokinaseRA, title={Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.}, author={Ying Rao Wei and Chi-Hui Tang and Young Kim and Liliane Robillard and Feng Zhang and Matthias Christian Kugler and Harold A Chapman}, journal={The Journal of biological chemistry}, year={2007}, volume={282 6}, pages={3929-39} }