Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.

@article{AguirreGhiso2001UrokinaseRA,
  title={Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.},
  author={Julio A. Aguirre-Ghiso and Dan Liu and Andrea Mignatti and Katherine A Kovalski and Laura L. Ossowski},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 4},
  pages={
          863-79
        }
}
We discovered that a shift between the state of tumorigenicity and dormancy in human carcinoma (HEp3) is attained through regulation of the balance between two classical mitogen-activated protein kinase (MAPK)-signaling pathways, the mitogenic extracellular regulated kinase (ERK) and the apoptotic/growth suppressive stress-activated protein kinase 2 (p38(MAPK)), and that urokinase plasminogen activator receptor (uPAR) is an important regulator of these events. This is a novel function for uPAR… CONTINUE READING

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Deregulation of the signaling pathways controlling urokinase production: its relationship with the invasive phenotype

  • J. A. Aguirre Ghiso, D. F. Alonso, E. F. Farias, D. E. Gomez, E. B. de Kier Joffe
  • Eur. J. Biochem
  • 1999
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