Urokinase plasminogen activator receptor: a functional integrator of extracellular proteolysis, cell adhesion, and signal transduction.

@article{Ferraris2013UrokinasePA,
  title={Urokinase plasminogen activator receptor: a functional integrator of extracellular proteolysis, cell adhesion, and signal transduction.},
  author={Gian Maria Sarra Ferraris and Nicolai Sidenius},
  journal={Seminars in thrombosis and hemostasis},
  year={2013},
  volume={39 4},
  pages={347-55}
}
The urokinase plasminogen activator receptor (uPAR) is a cell surface receptor involved in a multitude of physiologic and pathologic processes. uPAR regulates simultaneously a branch of the plasminogen activator system and modulates cell adhesion and intracellular signaling by interacting with extracellular matrix components and signaling receptors. The multiple uPAR functions are deeply interconnected, and their integration determines the effects that uPAR expression triggers in different… CONTINUE READING

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