Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge.

Abstract

Activated lymphocytes express urokinase-type plasminogen activator (uPA). Previous work suggests that uPA modulates T-lymphocyte responses. Mice deficient in uPA (uPA(-/-)) fail to generate type 1 (T1) immune responses during infection with Cryptococcus neoformans. Failure to generate either a T1 or a T2 immune response is not predictive of defects in the… (More)

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Cite this paper

@article{Gyetko2004UrokinasedeficientMF, title={Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge.}, author={Margaret R. Gyetko and Sudha Sud and Stephen W. Chensue}, journal={Infection and immunity}, year={2004}, volume={72 1}, pages={461-7} }